Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains

Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains

Background: Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency. Current treatments for OUD are unsuccessful in leading to lasting abstinence in most users. This underscores the lasting effects of chronic opioid use and emphasizes the need to understand the molecular m...

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Bibliographic Details
Main Authors: Micah A. Shelton, Nicole Horan, Xiangning Xue, Lisa Maturin, Darrell Eacret, Julie Michaud, Navsharan Singh, Benjamin R. Williams, Mackenzie C. Gamble, Joseph A. Seggio, Madeline K. Fish, BaDoi N. Phan, George C. Tseng, Julie A. Blendy, Leah C. Solberg Woods, Abraham A. Palmer, Olivier George, Ryan W. Logan, Marianne L. Seney
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Biological Psychiatry Global Open Science
Subjects:
Human
Morphine
Mouse
Opioids
Opioid use disorder
Oxycodone
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174325000308
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