GENETIC BIOMARKERS OF GLIAL BRAIN TUMORS: IDH1 AND IDH2 MUTATIONS

GENETIC BIOMARKERS OF GLIAL BRAIN TUMORS: IDH1 AND IDH2 MUTATIONS

Introduction. Mutations in the isocytrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are considered driver genetic events in gliomas. Their frequency reaches 7080 % in low-grade gliomas and in secondary glioblastomas, and their oncogenic effect is realized by accumulation of the metabolite 2-hydrox...

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Main Authors: M. Yu. Prokudin, B. V. Martynov, D. V. Svistov, I. V. Litvinenko, E. N. Imyanitov, V. S. Chirsky, S. E. Bushurov, A. I. Yakovenko, K. A. Chemodakova, O. A. Klitsenko, O. A. Gorustovich, G. F. Medvedeva, A. R. Bulatov
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2020-09-01
Series:Сибирский онкологический журнал
Subjects:
epilepsy
seizure
idh1 and idh2 gene mutations
gliomas
glioblastoma
anaplastic astrocytoma
diffuse astrocytoma
brain tumors
Online Access:https://www.siboncoj.ru/jour/article/view/1530
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