Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies

Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies

Abstract Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed millions of lives. The imminent threat of a panzootic outbreak of avian influenza H5N1 virus underscores the urgent need for pandemic preparedness and effective countermeasures, including monoclo...

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Main Authors: Julia Lederhofer, Andrew J. Borst, Lam Nguyen, Rebecca A. Gillespie, Connor J. Williams, Emma L. Walker, Julie E. Raab, Christina Yap, Daniel Ellis, Adrian Creanga, Hyon-Xhi Tan, Thi H. T. Do, Michelle Ravichandran, Adrian B. McDermott, Valerie Le Sage, Sarah F. Andrews, Barney S. Graham, Adam K. Wheatley, Douglas S. Reed, Neil P. King, Masaru Kanekiyo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62339-z
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https://doi.org/10.1038/s41467-025-62339-z

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