Bioorthogonal click chemistry-mediated conjugation of an anti-DR4 antibody to gold nanorods enhances its pro-apoptotic activity under near infra-red-light stimulation

Bioorthogonal click chemistry-mediated conjugation of an anti-DR4 antibody to gold nanorods enhances its pro-apoptotic activity under near infra-red-light stimulation

Pro-apoptotic receptor activators (PARAs), including second-generation agonist antibodies and ligands targeting the TNF receptor superfamily such as TRAIL (TNF-Related Apoptosis-Inducing Ligand), represent a promising class of cancer therapeutics. Enhancing their apoptotic efficacy through multivale...

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Bibliographic Details
Main Authors: Abdelmnim Radoua, Mélanie Romain, Elisa Chazeau, Nadège Marthouret, Fabien Picaud, Guillaume Herlem, Christine Goze, Nadine Millot, Olivier Micheau
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Materials & Design
Subjects:
Gold nanorods
Pro-apoptotic receptor activators
Strain promoted azide-alkyne cycloaddition
NIR activation
Anti-tumor therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S026412752500632X
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