A multi-centre, participant-blinded, randomized, 3-year study to compare the efficacy of Virtual Surgical Planning (VSP) to Freehand Surgery (FHS) on bony union and quality of life outcomes for mandibular reconstruction with fibular and scapular free flaps: study protocol for a randomized phase II/III trial

A multi-centre, participant-blinded, randomized, 3-year study to compare the efficacy of Virtual Surgical Planning (VSP) to Freehand Surgery (FHS) on bony union and quality of life outcomes for mandibular reconstruction with fibular and scapular free flaps: study protocol for a randomized phase II/III trial

Abstract Background Advanced head and neck malignancies with underlying bony involvement often require aggressive oncological resection of large segments of the oral cavity including the mandible. These patients require vascularized donor osseous free tissue transfer to reconstruct significant defec...

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Main Authors: Khanh Linh Tran, Sena Turkdogan, Anat Bahat Dinur, Thomas D. Milner, Edward Wang, Anthony Nichols, Danielle MacNeil, Adrian Mendez, Jake Jervis-Bardy, John De Almeida, Christopher Yao, David Goldstein, Ralph Gilbert, Antoine Eskander, Kevin Higgins, Danny Enepekides, Michael Gupta, Han Zhang, Michael Au, Sally Nguyen, Sidney Fels, Antony Hodgson, Penelope Brasher, Craig Mitton, Farahna Sabiq, Charles Fisher, David Yang, Angela Wong, Cathie Garnis, Catherine Poh, J. Scott Durham, Eitan Prisman
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Head and neck cancer
Oral cavity
Mandible Reconstruction
Virtual Surgical Planning
Quality of life
Randomized controlled trial
Online Access:https://doi.org/10.1186/s12885-025-13505-5
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https://doi.org/10.1186/s12885-025-13505-5

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