IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes

IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes

Summary: Alpha-kinase 1 (ALPK1) is an immune receptor sensing the bacterial nucleotide sugar ADP-heptose. ALPK1 phosphorylates TIFA leading to its oligomerization and downstream NF-κB activation. Specific mutations in ALPK1 are associated with an autoinflammatory syndrome termed ROSAH and with spira...

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Bibliographic Details
Main Authors: Amandine Martin, Solène Caron, Mélissa Marcotte, Pauline Bronnec, Etienne Garneret, Nora Martel, Georgina Maalouf, Pascal Sève, David Saadoun, Yvan Jamilloux, Thomas Henry
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027901
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