Deep sequencing of circulating tumour DNA as a biomarker of clinical outcome to transarterial chemoembolisation in hepatocellular carcinoma

Abstract Survival following transarterial chemoembolisation (TACE) for hepatocellular cancer (HCC) is variable. We explored targeted sequencing of circulating tumour DNA (ctDNA) as a prognostic biomarker. Plasma samples (n = 97) were collected at baseline and following TACE. Targeted, ultra-deep seq...

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Bibliographic Details
Main Authors: Rohini Sharma, Sultan N. Alharbi, Ksenia Ellum, Leila Motedayen-Aval, Andrea Casadei-Gardini, David J. Pinato, Dominik Bettinger, Bertram Bengsch, Rishi Patel, Joanne Evans
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00961-2
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