Analysis of damaging non-synonymous SNPs in GPx1 gene associated with the progression of diverse cancers through a comprehensive in silico approach

Analysis of damaging non-synonymous SNPs in GPx1 gene associated with the progression of diverse cancers through a comprehensive in silico approach

Abstract Glutathione Peroxidase 1 (GPx1) gene has been reported for its role in cellular redox homeostasis, and the dysregulation of its expression is linked with the progression of diverse cancers. Non-synonymous single nucleotide polymorphism (nsSNPs) have been emerged as the crucial factors, play...

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Bibliographic Details
Main Authors: Muhammad Waleed Iqbal, Muhammad Shahab, Guojun Zheng, Xinxiao Sun, Qipeng Yuan, Khalid S. Almaary, Gezahign Fentahun Wondmie, Mohammed Bourhia
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
GPx1
Cancer
NsSNPs
Mutational analysis
In-silico analysis
Online Access:https://doi.org/10.1038/s41598-024-78232-6
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https://doi.org/10.1038/s41598-024-78232-6

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