8-Epidiosbulbin E acetate triggers apoptosis via metabolic activation-mediated crosstalk between mitochondria and endoplasmic reticulum

8-Epidiosbulbin E acetate triggers apoptosis via metabolic activation-mediated crosstalk between mitochondria and endoplasmic reticulum

8-Epidiosbulbin E acetate (EEA), a furan-containing diterpenoid lactone and key component of Dioscorea bulbifera L., has been found to induce notable liver injury in mice through CYP3A-mediated metabolic activation to a cis-enedial reactive metabolite. EEA exposure at 25, 50, 100, or 200 µM triggere...

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Bibliographic Details
Main Authors: Shiyu Zhang, Bowen Gong, Rong Tan, Yufen Liao, Xin Wang, Xu Wang, Ying Liu, Ting Liu, Jun Luo, Weiwei Li, Jia Yu, Ying Peng, Jiang Zheng
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
8-Epidiosbulbin E acetate
Metabolic activation
Reactive oxygen species
Apoptosis
Mitochondrial pathway
Endoplasmic reticulum pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325009595
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