Gentisic acid prevents the development of atherosclerotic lesions by inhibiting SNX10-mediated stabilization of LRP6

Gentisic acid prevents the development of atherosclerotic lesions by inhibiting SNX10-mediated stabilization of LRP6

Atherosclerotic-related acute cardiovascular events remain a leading cause of mortality worldwide, yet there are currently no pharmacological interventions available to address plaque formation or plaque rupture (PR). Here we reported that gentisic acid (GA) exerted potent therapeutic effects on pla...

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Bibliographic Details
Main Authors: Tongqing Chen, Yiming Wang, Jia-Lin Yang, Jiahui Ni, Keyuan You, Xuesong Li, Yuping Song, Xu Wang, Jian Li, Xiaoyan Shen, Yujuan Fan, Yan You
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
Gentisic acid
Plaque rupture
LRP6
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004614
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