Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria

Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria

Abstract CprA is a short‐chain dehydrogenase/reductase (SDR) that contributes to resistance against colistin and antimicrobial peptides. The cprA gene is conserved across Pseudomonas aeruginosa clades and its expression is directly regulated by the two‐component system PmrAB. We have shown that cprA...

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Main Authors: Audrey Goman, Bérengère Ize, Katy Jeannot, Camille Pin, Delphine Payros, Cécile Goursat, Léa Ravon‐Katossky, Kazunori Murase, Camille V. Chagneau, Hélène Revillet, Frédéric Taieb, Sophie Bleves, Laure David, Etienne Meunier, Priscilla Branchu, Eric Oswald
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of Extracellular Vesicles
Subjects:
autophagy
inflammasome
OMVs
pathogenicity
PmrAB
polymyxins
Online Access:https://doi.org/10.1002/jev2.70032
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https://doi.org/10.1002/jev2.70032

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