BHLHE40 contributes to allergic asthma progression in mice through NRTN downregulation in macrophages

Abstract Alternatively activated M2-like macrophages have a profound impact on asthma pathogenesis. Basic Helix-Loop-Helix Family Member E40 (BHLHE40), a dimeric transcriptional factor, plays a key regulation in macrophage functions. Here we show that ovalbumin (OVA)-challenged mice exhibited greate...

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Bibliographic Details
Main Authors: Bing Dai, Li Chen, Xiaowen Li, Qianlan Zhou, Qinzhen Zhang, Lina Han, Wenxin Shen, Qing Chang, Yuhong Zhao, Si Liu, Lishen Shan
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08288-1
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