Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases

Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases

Abstract Protein kinases are critical components of a myriad biological processes and strongly associated with various diseases. While kinase research has been a point of focus in biomedical research for several decades, a large portion of the kinome is still considered understudied or “dark,” becau...

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Main Authors: Abdul-rizaq Hamoud, Khaled Alganem, Sean Hanna, Michael Morran, Nicholas Henkel, Ali S. Imami, William Ryan, Smita Sahay, Priyanka Pulvender, Austin Kunch, Taylen O. Arvay, Jarek Meller, Rammohan Shukla, Sinead M. O’Donovan, Robert McCullumsmith
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Cell Communication and Signaling
Online Access:https://doi.org/10.1186/s12964-024-01868-4
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https://doi.org/10.1186/s12964-024-01868-4

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