Design and synthesis of polymer nanoparticles with pH-responsive pan-HDAC inhibitor (C5) derived from norbornene block copolymers to increase C5 solubility and improve its targeted delivery to prostate cancer sites

Design and synthesis of polymer nanoparticles with pH-responsive pan-HDAC inhibitor (C5) derived from norbornene block copolymers to increase C5 solubility and improve its targeted delivery to prostate cancer sites

This study investigated the incorporation of C5, a pan-HDAC inhibitor, into a norbornene-derived block copolymer with pH-sensitive hydrolysis (PNEG-b-P(Nor-PABA-C5)) to generate NPs for prostate cancer treatment. Amphiphilic PNEG-b-P(Nor-PABA-C5) formed NPs in aqueous environments, with hydrophobic...

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Bibliographic Details
Main Authors: Jacob Mathew, Anshul Mishra, Trong-Nghia Le, Jing-Ping Liou, Mei-Jung Lai, Vijayakameswara Rao Neralla
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
pan-HDAC inhibitors (HDACi)
norbornene-derived block copolymer
hydrolysis
PC-3 prostate cancer cells
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2530557
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https://www.tandfonline.com/doi/10.1080/14756366.2025.2530557

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