M2-like macrophages derived from THP-1 cells promote myofibroblast differentiation of synovial fibroblasts in association with the TGF-β1/SMAD2/3 signaling pathway

M2-like macrophages derived from THP-1 cells promote myofibroblast differentiation of synovial fibroblasts in association with the TGF-β1/SMAD2/3 signaling pathway

Abstract Fibrosis occurs during progression of osteoarthritis (OA), and myofibroblasts are considered a key effector to drive the fibrotic response. Macrophages also play critical roles in OA progression. However, whether macrophage polarization is involved in OA-related fibrosis has not been adequa...

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Main Authors: Nguyen Tran Canh Tung, Makiko Nogami, Mami Iwasaki, Yasuhito Yahara, Shoji Seki, Hiroto Makino, Katsuhiko Kamei, Zhongyuan He, Yoshiharu Kawaguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Osteoarthritis
Fibrosis
Macrophages
Human synovial fibroblast
Myofibroblast
TGF-β/SMAD signaling
Online Access:https://doi.org/10.1038/s41598-025-10858-6
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https://doi.org/10.1038/s41598-025-10858-6

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