Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects

Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects

Abstract Background Our team has previously found that the stimulator of interferon genes (STING) plays a more significant anti-tumor role in host immune cells than in tumor cells. Although STING is necessary for CD8 + T cells to exert immunological activity, its effect on CD8 + T cells remains deba...

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Bibliographic Details
Main Authors: Qiuli Xu, Xin Hua, Bingbing Li, Bei Jiang, Jiajia Jin, Ranpu Wu, Yanli Gu, Hao Xu, Qinpei Cheng, Suhua Zhu, Fang Zhang, Tangfeng Lv, Yong Song
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
STING
CD8 + T cells
Metabolic reprogramming
Glycolysis
Non-small cell lung cancer
Immunotherapy
Online Access:https://doi.org/10.1186/s12964-025-02069-3
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https://doi.org/10.1186/s12964-025-02069-3

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