Endolysosomal pathway activity protects cells from neurotoxic TDP-43

Endolysosomal pathway activity protects cells from neurotoxic TDP-43

The accumulation of protein aggregates in neurons is a typical pathological hallmark of the motor neuron disease amyotrophic lateral sclerosis (ALS) and of frontotemporal dementia (FTD). In many cases, these aggregates are composed of the 43 kDa TAR DNA-binding protein (TDP‑43). Using a yeast model...

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Bibliographic Details
Main Authors: Christine Leibiger, Jana Deisel, Andreas Aufschnaiter, Stefanie Ambros, Maria Tereshchenko, Bert M. Verheijen, Sabrina Büttner, Ralf J. Braun
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-03-01
Series:Microbial Cell
Subjects:
motor neuron disease
amyotrophic lateral sclerosis
frontotemporal dementia
TDP-43
protein aggregation
proteolysis
endolysosomal pathway
endosomal-vacuolar pathway
endocytosis
vacuole
lysosomes
autophagy
cell death
Saccharomyces cerevisiae
Online Access:http://microbialcell.com/researcharticles/endolysosomal-pathway-activity-protects-cells-from-neurotoxic-tdp-43/
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