Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis

Translating medication effects for alcohol use disorder across preclinical, human laboratory, and clinical trial outcomes using meta-analysis

Abstract Animal models are used for preliminary testing of novel compounds for alcohol use disorder (AUD). However, it is unclear whether early efficacy in preclinical models reliably predicts efficacy in human laboratory and clinical trials. We searched the literature for medications tested for AUD...

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Main Authors: Steven J. Nieto, Suzanna Donato, Han Du, Lindsay R. Meredith, Wave-Ananda Baskerville, Kaitlin R. McManus, Molly Magill, Marcelo F. Lopez, Howard C. Becker, Lara A. Ray
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03473-6
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https://doi.org/10.1038/s41398-025-03473-6

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