Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis

Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis

PurposeThis study aims to investigate the efficacy and safety of PD-1/PD-L1 inhibitors in the first-line treatment of esophageal squamous cell carcinoma (ESCC) and identify factors influencing efficacy through a meta-analysis of multiple phase 3 randomized controlled trials (RCTs).MethodsA systemati...

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Bibliographic Details
Main Authors: Wei Ren, Hanyu Zhang, Yixin Li, Wu Sun, Hexiang Peng, Huangda Guo, Tianjiao Hou, Mengying Wang, Zhendong Hu, Tao Wu, Baorui Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
PD-1/PD-L1 inhibitor
esophageal squamous cell carcinoma
meta-analysis
immunotherapy
combined positive score
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563300/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563300/full

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