Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDA) is an extremely aggressive malignancy, which carries a dismal prognosis. Activating mutations of the Kras gene are common to the vast majority of human PDA. In addition, recent studies have demonstrated that embryonic signaling pathway such as Hedgehog and Notc...

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Main Authors: Marina Pasca di Magliano, Andrew V Biankin, Patrick W Heiser, David A Cano, Pedro J A Gutierrez, Therese Deramaudt, Davendra Segara, Amanda C Dawson, James G Kench, Susan M Henshall, Robert L Sutherland, Andrzej Dlugosz, Anil K Rustgi, Matthias Hebrok
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-11-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001155&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001155&type=printable

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