Glutamine-driven metabolic reprogramming promotes CAR-T cell function through mTOR-SREBP2 mediated HMGCS1 upregulation in ovarian cancer

Glutamine-driven metabolic reprogramming promotes CAR-T cell function through mTOR-SREBP2 mediated HMGCS1 upregulation in ovarian cancer

Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy holds promise for cancer treatment, but its efficacy is often hindered by metabolic constraints in the tumor microenvironment. This study investigates the role of glutamine in enhancing CAR-T cell function against ovarian cancer. M...

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Main Authors: Jiannan Chen, Lianfeng Zhao, Wenying Li, Shuai Wang, Jiayi Li, Zhongyuan Lv, Yaoyao Zhao, Junqing Liang, Zhigang Hu, Feiyan Pan, Lingfeng He, Lili Gu, Zhigang Guo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
CAR-T cell therapy
T cell exhaustion
Glutamine
MTOR-SREBP2 Axis
HMGCS1
Ovarian cancer
Online Access:https://doi.org/10.1186/s12967-025-06853-0
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https://doi.org/10.1186/s12967-025-06853-0

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