Unveiling the role of Ndrg1 gene on the oxidative stress induction behind the anticancer potential of styrylquinazoline derivatives

Unveiling the role of Ndrg1 gene on the oxidative stress induction behind the anticancer potential of styrylquinazoline derivatives

Abstract This work presents a multifaceted mechanism of the anticancer action of a 2-styrylquinazoline derivative. Extensive analysis of various aspects related to tyrosine kinase inhibition and effects on cellular targets at both the gene and protein levels revealed the potential of this IS20 compo...

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Main Authors: Katarzyna Malarz, Michał Kuczak, Patryk Rurka, Patrycja Rawicka, Anna Boguszewska-Czubara, Josef Jampilek, Jacek Mularski, Robert Musiol, Anna Mrozek-Wilczkiewicz
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Anticancer drug
Styrylquinazoline
Oxidative stress
Iron chelator
Ndrg1
p53 protein
Online Access:https://doi.org/10.1038/s41598-025-99277-1
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https://doi.org/10.1038/s41598-025-99277-1

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