Phenothiazine Conjugate with Mitochondria-Directed Cationic Compound F16: Synthesis and Cytotoxic Action against Human Breast Carcinoma

Phenothiazine Conjugate with Mitochondria-Directed Cationic Compound F16: Synthesis and Cytotoxic Action against Human Breast Carcinoma

The development of new drugs or drug candidates based on the phenothiazine system (10H-dibenzo-[b,e]-1,4-thiazine) is a promising approach in view of the diverse biological activity of this tricyclic system, which is present in traditional drugs (chlorpromazine, thioridazine, trifluoperazine, and tr...

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Bibliographic Details
Main Authors: Eldar Davletshin, Darya Nedopekina, Rezeda Khalitova, Mikhail Dubinin, Konstantin Belosludtsev, Anna Spivak
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Chemistry Proceedings
Subjects:
phenothiazine
conjugates
mitochondria
delocalized lypophilic cations
F16
anti-cancer activity
Online Access:https://www.mdpi.com/2673-4583/14/1/49
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