Identification of novel amides and alkaloids as putative inhibitors of dopamine transporter for schizophrenia using computer-aided virtual screening

Identification of novel amides and alkaloids as putative inhibitors of dopamine transporter for schizophrenia using computer-aided virtual screening

Schizophrenia is a complex psychiatric disorder marked by delusions, memory impairments, hallucinations, disorganized behavior, and severe cognitive deficits. Targeting the dopamine transporter (DAT) protein is promising for treating cognitive symptoms, especially in patients resistant to antipsycho...

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Bibliographic Details
Main Authors: Iqra Ahmad, Anam Tassawer, Muhammad Umer Khan, Muhammad Shehroz, Umar Nishan, Sheheryar Sheheryar, Hanna Dib, Mohamed A. O. Abdelfattah, Mohibullah Shah
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
medicinal plants
antipsychotic treatment
phytochemicals
drug designing
in-silico
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1509263/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1509263/full

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