Effect-Size Discrepancies in Literature Versus Raw Datasets from Experimental Spinal Cord Injury Studies: A CLIMBER Meta-Analysis

Effect-Size Discrepancies in Literature Versus Raw Datasets from Experimental Spinal Cord Injury Studies: A CLIMBER Meta-Analysis

Translation of spinal cord injury (SCI) therapeutics from pre-clinical animal studies into human studies is challenged by effect size variability, irreproducibility, and misalignment of evidence used by pre-clinical versus clinical literature. Clinical literature values reproducibility, with the hig...

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Bibliographic Details
Main Authors: Emma G. Iorio, Alireza Khanteymoori, Kenneth A. Fond, Anastasia V. Keller, Lex Maliga Davis, Jan M. Schwab, Adam R. Ferguson, Abel Torres-Espin, Ralf Watzlawick
Format: Article
Language:English
Published: Mary Ann Liebert 2024-11-01
Series:Neurotrauma Reports
Subjects:
individual animal data (IAD)
literature-extracted data (LED)
meta-analysis
meta-science
spinal cord injury (SCI)
systematic review
Online Access:https://www.liebertpub.com/doi/10.1089/neur.2024.0038
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