Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables

Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables

Abstract Background Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes (T1D), arising from relative insulin deficiency and leading to hyperglycemia, ketonemia, and metabolic acidosis. Early detection and treatment are essential to prevent severe outcomes. This pediatric case–co...

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Bibliographic Details
Main Authors: Paolo Spagnolo, David Tweddell, Enis Cela, Mark Daley, Cheril Clarson, C. Anthony Rupar, Saverio Stranges, Michael Bravo, Gediminas Cepinskas, Douglas D. Fraser
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Pediatric
Diabetic ketoacidosis
Metabolomics
Metabolites
Pathways
Panels
Online Access:https://doi.org/10.1186/s10020-024-01046-9
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https://doi.org/10.1186/s10020-024-01046-9

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