Multiomic Sequencing Reveals Distinctive Gene Expression and Epigenetic Alterations Associated With Primary Sclerosing Cholangitis Development in Treatment-Naïve Pediatric Ulcerative Colitis

Multiomic Sequencing Reveals Distinctive Gene Expression and Epigenetic Alterations Associated With Primary Sclerosing Cholangitis Development in Treatment-Naïve Pediatric Ulcerative Colitis

Background and Aims: Primary sclerosing cholangitis (PSC) is a progressive cholestatic disease with up to 80% of patients also suffering from ulcerative colitis (PSC-UC). The difficulty in the diagnosis along with the increased risk for developing cancer represents a clinical challenge. Furthermore,...

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Main Authors: Alejandra Rodriguez-Sosa, Ololade Lawal, Ciaran McDonnell, Luke Grant, John O’Brien, Muhammad Ali, Ian Stephens, Grainne Kirwan, Flavia Genua, Alexander Kel, Anna Dominik, Roisin Stack, Gregory Yochum, Michael McDermot, Glen Doherty, Seamus Hussey, Sudipto Das
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Gastro Hep Advances
Subjects:
Primary Sclerosing Cholangitis
Ulcerative Colitis
Transcriptional Regulation
Methylation Profiling
Online Access:http://www.sciencedirect.com/science/article/pii/S2772572324001821
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