α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback

α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback

A previously identified anti-rheumatic compound α-mangostin (MAN) possesses notable metabolism regulatory properties. In this study, we investigated the immune implication of MAN-altered fat metabolism on adjuvant-induced arthritis (AIA) in rats. Seven days after AIA induction, the rats received ora...

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Bibliographic Details
Main Authors: Ying-Hao Hu, Jun Han, Lin Wang, Chao Shi, Yan Li, Opeyemi Joshua Olatunji, Xiu Wang, Jian Zuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
macrophage
rheumatoid arthritis
PPAR-γ
adjuvant- induced arthritis
fat metabolism
adipocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.692806/full
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https://www.frontiersin.org/articles/10.3389/fphar.2021.692806/full

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