Divergent dimerization mechanisms and conserved DNA-binding function in PFam12 proteins of Borrelia burgdorferi

Divergent dimerization mechanisms and conserved DNA-binding function in PFam12 proteins of Borrelia burgdorferi

Abstract Lyme disease, caused by the spirochete Borrelia burgdorferi, is transmitted to mammalian hosts during the feeding process of infected Ixodes ticks. Our previous studies demonstrated that the paralogous gene family 12 (PFam12) consisting of five members (BBK01, BBG01, BBH37, BBJ08, and BB084...

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Bibliographic Details
Main Authors: Kalvis Brangulis, Dagnija Tupina, Everita Elina Sinicina, Diana Zelencova-Gopejenko, Inara Akopjana, Janis Bogans, Kaspars Tars
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Lyme disease
Borreliosis
DNA-binding protein
x-ray-crystallography
Molecular dynamics
Online Access:https://doi.org/10.1038/s41598-025-93944-z
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https://doi.org/10.1038/s41598-025-93944-z

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