Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle

Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle

Abstract Background We recently reported that the ovarian cancer G protein-coupled receptor-1 (OGR1) can be pharmacologically biased with specific benzodiazepines to couple with distinct heterotrimeric G proteins in human airway smooth muscle (ASM) cells. Lorazepam stimulated both Gs and Gq signalin...

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Main Authors: Dominic R. Villalba, Arun K. Jannu, Elham Javed, Isha Dandekar, Ruping Wang, Deepak A. Deshpande, Steven S. An, Reynold A. Panettieri, Dale D. Tang, Raymond B. Penn, Ajay P. Nayak
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
Subjects:
Benzodiazepines
Airway smooth muscle
OGR1
GPCR
Online Access:https://doi.org/10.1186/s12931-025-03268-9
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https://doi.org/10.1186/s12931-025-03268-9

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