Lymph node transcriptomic profiles suggest susceptibility to bleomycin-induced pulmonary toxicity in classic hodgkin lymphoma

Lymph node transcriptomic profiles suggest susceptibility to bleomycin-induced pulmonary toxicity in classic hodgkin lymphoma

Abstract Despite advances in reducing treatment-related toxicities, predictive biomarkers for bleomycin-induced pulmonary toxicity (BPT) remain undefined. Affecting around 10% of classic Hodgkin lymphoma (CHL) and associated with a mortality rate of 10–20%, BPT poses a clinical challenge. This study...

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Bibliographic Details
Main Authors: Maja Dam Andersen, Marie Hairing Enemark, Kristina Lystlund Lauridsen, Stephen Jacques Hamilton-Dutoit, Jørn Starklint, Francesco d’Amore, Maja Ludvigsen, Peter Kamper
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Bleomycin pulmonary toxicity (BPT)
Classic hodgkin lymphoma (CHL)
FFPE-tissue
Nanostring
Gene expression
Online Access:https://doi.org/10.1038/s41598-025-16218-8
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https://doi.org/10.1038/s41598-025-16218-8

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