Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial CellsSUMMARY

Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial CellsSUMMARY

Background & Aims: Congestion alters the microenvironment of the liver sinusoid along the portal-central axis. We studied spatial changes in immune cells in the sinusoid that contribute to congestive fibrosis and portal hypertension (PHTN). Methods: To visualize the distribution of immune ce...

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Main Authors: Siyuan Ma, Nawras W. Habash, Mrunal K. Dehankar, Nidhi Jalan-Sakrikar, Shawna A. Cooper, Abid A. Anwar, Sofia Jerez, Papawee Sutthirat, Jinhang Gao, Tamir Diamond, Jing Jiao, Caixin Qiu, Jingchun Yang, Sumera I. Ilyas, Markcus Lee, Usman Yaqoob, Sheng Cao, Rebecca G. Wells, Vijay H. Shah, Moira B. Hilscher
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Fontan-associated Liver Disease
Fibrosis
Hypoxia
Imaging Mass Cytometry
Portal Hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000165
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