Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses

Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses

Abstract Background Bacterial vaginosis (BV) affects 20–50% of reproductive-age female patients annually, arising when opportunistic pathogens outcompete healthy vaginal flora. Many patients fail to resolve symptoms with a course of metronidazole, the current first-line treatment for BV. Our study w...

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Main Authors: Katherine A. Innamorati, Joshua P. Earl, Shirley C. Barrera, Rachel L. Ehrlich, Josephine Aiyeku, Ari Gordon, Evan Powell, Adam C. Retchless, Azad Ahmed, Bhaswati Sen, Sergey Balashov, Joshua Chang Mell, Sharon L. Hillier, Garth D. Ehrlich
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Medicine
Subjects:
Comparative genomics
Pangenome
Supragenome
Distributed genome hypothesis
Antibiotic resistance
Bacterial vaginosis
Online Access:https://doi.org/10.1186/s13073-025-01446-4
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https://doi.org/10.1186/s13073-025-01446-4

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