Perindopril Ameliorates Sodium Valproate-Induced Rat Model of Autism: Involvement of Sirtuin-1, JAK2/STAT3 Axis, PI3K/Akt/GSK-3β Pathway, and PPAR-Gamma Signaling

Perindopril Ameliorates Sodium Valproate-Induced Rat Model of Autism: Involvement of Sirtuin-1, JAK2/STAT3 Axis, PI3K/Akt/GSK-3β Pathway, and PPAR-Gamma Signaling

<i>Background and Objectives:</i> Autism is a developmental disability characterized by impairment of motor functions and social communication together with the development of repetitive or stereotyped behaviors. Neither the exact etiology or the curative treatment of autism are yet comp...

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Main Authors: Anwar M. Alnakhli, Asmaa Saleh, Ahmed M. Kabel, Remon S. Estfanous, Hany M. Borg, Khulud M. Alsufyani, Nesreen M. Sabry, Fatma Alzahraa M. Gomaa, Maaly A. Abd Elmaaboud
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Medicina
Subjects:
autism
perindopril
valproic acid
neuroinflammation
apoptosis
rats
Online Access:https://www.mdpi.com/1648-9144/60/11/1802
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