Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

The TCR-mediated activation of T cells expressing the TCR Vγ9Vδ2 relies on an innate-like mechanism involving the butyrophilin 3A1, 3A2 and 2A1 molecules and phospho-antigens, without the participation of classical antigen-presenting molecules. Whether TCR Vγ9Vδ2 cells also recognize complexes compo...

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Bibliographic Details
Main Authors: José Pedro Loureiro, Alessandro Vacchini, Giuliano Berloffa, Jan Devan, Verena Schaefer, Vladimir Nosi, Rodrigo Colombo, Aisha Beshirova, Giulia Montanelli, Benedikt Meyer, Timothy Sharpe, Andrew Chancellor, Mike Recher, Lucia Mori, Gennaro De Libero
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
MR1
TCR γδ
Vγ9Vδ2
adaptive immunity
antigen recognition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519128/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519128/full

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