RvD2 mitigates TNFɑ-Induced mitochondrial reactive oxygen species through NRF2 signaling in placental trophoblasts

RvD2 mitigates TNFɑ-Induced mitochondrial reactive oxygen species through NRF2 signaling in placental trophoblasts

IntroductionHypertensive disorders of pregnancy (HDP) are marked by elevated levels of TNFα, which increases reactive oxygen species (ROS) and disrupts metabolism of trophoblasts. Resolvin D2 (RvD2), an omega‐3 fatty acid-derived lipid mediator, is known to resolve inflammation, but its role in prot...

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Main Authors: Taija Hahka, Deekshika Sekar, Prakash Kumar Sahoo, Aiswariya Ravi, Colman Freel, Chandan Krishnamoorthy, Sankar Ramamurthy, Rebekah Rapoza, Rebecca Drakowski, Anum Akbar, Matt VanOrmer, Melissa Thoene, Corrine K. Hanson, Tara Nordgren, Sathish Kumar Natarajan, Ann Anderson Berry
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Physiology
Subjects:
hypertensive disorders of pregnancy
omega-3 fatty acids
oxidative stress
glutathione
metabolism
superoxide
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1547940/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1547940/full

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