Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway

Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway

BackgroundFertility preservation is a critical concern for reproductive-age cancer survivors, as conventional cytotoxic therapies can cause irreversible damage to the reproductive system, potentially depriving them of the ability to have children in the future. Immune checkpoint inhibitors (ICIs), i...

Full description

Saved in:
Bibliographic Details
Main Authors: Halahati· Tuerxun, Yixin Zhao, Yawen Li, Xingyu Liu, Shuhui Wen, Yuguang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitors
anti-programmed cell death protein 1
reproductive toxicity
oxidative stress
ferroptosis
resveratrol
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529991/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529991/full

Similar Items