Oncogenic and microenvironmental signals drive cell type specific apoptosis resistance in juvenile myelomonocytic leukemia

Oncogenic and microenvironmental signals drive cell type specific apoptosis resistance in juvenile myelomonocytic leukemia

Abstract Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signaling and characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using MxCre;Ptpn11 D61Y/+ mice, which model human JMML, we show that RAS pathway ac...

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Main Authors: Naile Koleci, Ying Wu, Niels Anton Wehner, Jovana Rajak, Venugopal Rao Mittapalli, Julia Mergner, Hui Xiao, Jun Wang, Madeleine Wahl, Sheila Bohler, Konrad Aumann, Georg Häcker, Senthilkumar Ramamoorthy, Melanie Boerries, Susanne Kirschnek, Miriam Erlacher
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07479-2
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https://doi.org/10.1038/s41419-025-07479-2

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