PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs
Background: The importance of caspase-2 activation for mediating apoptosis in cancer is not clear and seems to differ between different tumour types. Furthermore, only few data have been obtained concerning the expression of caspase-2, which can be alternatively spliced into caspase-2L and caspase-2...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0492 |
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| _version_ | 1832566592897024000 |
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| author | Sebastian Heikaus Igor Pejin Helmut Erich Gabbert Uwe Ramp Csaba Mahotka |
| author_facet | Sebastian Heikaus Igor Pejin Helmut Erich Gabbert Uwe Ramp Csaba Mahotka |
| author_sort | Sebastian Heikaus |
| collection | DOAJ |
| description | Background: The importance of caspase-2 activation for mediating apoptosis in cancer is not clear and seems to differ between different tumour types. Furthermore, only few data have been obtained concerning the expression of caspase-2, which can be alternatively spliced into caspase-2L and caspase-2S, and the other PIDDosome members PIDD and RAIDD in human tumours in vivo. We, therefore, investigated their expression in renal cell carcinomas (RCCs) of the clear cell type in vivo and analysed the role of caspase-2 in chemotherapy-induced apoptosis in RCCs in vitro. |
| format | Article |
| id | doaj-art-0e5c1332b20f4a9ea865973ab3126219 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-0e5c1332b20f4a9ea865973ab31262192025-02-03T01:03:43ZengWileyCellular Oncology1570-58701875-86062010-01-01321-2294210.3233/CLO-2009-0492PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCsSebastian Heikaus0Igor Pejin1Helmut Erich Gabbert2Uwe Ramp3Csaba Mahotka4Institute of Pathology, Heinrich-Heine University Hospital, Düsseldorf, GermanyInstitute of Pathology, Heinrich-Heine University Hospital, Düsseldorf, GermanyInstitute of Pathology, Heinrich-Heine University Hospital, Düsseldorf, GermanyInstitute of Pathology, Heinrich-Heine University Hospital, Düsseldorf, GermanyInstitute of Pathology, Heinrich-Heine University Hospital, Düsseldorf, GermanyBackground: The importance of caspase-2 activation for mediating apoptosis in cancer is not clear and seems to differ between different tumour types. Furthermore, only few data have been obtained concerning the expression of caspase-2, which can be alternatively spliced into caspase-2L and caspase-2S, and the other PIDDosome members PIDD and RAIDD in human tumours in vivo. We, therefore, investigated their expression in renal cell carcinomas (RCCs) of the clear cell type in vivo and analysed the role of caspase-2 in chemotherapy-induced apoptosis in RCCs in vitro.http://dx.doi.org/10.3233/CLO-2009-0492 |
| spellingShingle | Sebastian Heikaus Igor Pejin Helmut Erich Gabbert Uwe Ramp Csaba Mahotka PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs Cellular Oncology |
| title | PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs |
| title_full | PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs |
| title_fullStr | PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs |
| title_full_unstemmed | PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs |
| title_short | PIDDosome Expression and the Role of Caspase-2 Activation for Chemotherapy-Induced Apoptosis in RCCs |
| title_sort | piddosome expression and the role of caspase 2 activation for chemotherapy induced apoptosis in rccs |
| url | http://dx.doi.org/10.3233/CLO-2009-0492 |
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