Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response
The DNA replication machinery is highly conserved from bacteria to eukaryotic cells. Faithful DNA replication is vital for cells to transmit accurate genetic information to the next generation. However, both internal and external DNA damages threaten the intricate DNA replication process, leading to...
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MDPI AG
2024-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/1/12 |
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| author | Agnes Malysa Xiaohong Mary Zhang Gerold Bepler |
| author_facet | Agnes Malysa Xiaohong Mary Zhang Gerold Bepler |
| author_sort | Agnes Malysa |
| collection | DOAJ |
| description | The DNA replication machinery is highly conserved from bacteria to eukaryotic cells. Faithful DNA replication is vital for cells to transmit accurate genetic information to the next generation. However, both internal and external DNA damages threaten the intricate DNA replication process, leading to the activation of the DNA damage response (DDR) system. Dysfunctional DNA replication and DDR are a source of genomic instability, causing heritable mutations that drive cancer evolutions. The family of minichromosome maintenance (MCM) proteins plays an important role not only in DNA replication but also in DDR. Here, we will review the current strides of MCM proteins in these integrated processes as well as the acetylation/deacetylation of MCM proteins and the value of MCMs as biomarkers in cancer. |
| format | Article |
| id | doaj-art-0e467442bb9a4545bd526184f6645220 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-0e467442bb9a4545bd526184f66452202025-01-10T13:16:14ZengMDPI AGCells2073-44092024-12-011411210.3390/cells14010012Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage ResponseAgnes Malysa0Xiaohong Mary Zhang1Gerold Bepler2Karmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, 4100 John R Street, Detroit, MI 48201, USAKarmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, 4100 John R Street, Detroit, MI 48201, USAKarmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, 4100 John R Street, Detroit, MI 48201, USAThe DNA replication machinery is highly conserved from bacteria to eukaryotic cells. Faithful DNA replication is vital for cells to transmit accurate genetic information to the next generation. However, both internal and external DNA damages threaten the intricate DNA replication process, leading to the activation of the DNA damage response (DDR) system. Dysfunctional DNA replication and DDR are a source of genomic instability, causing heritable mutations that drive cancer evolutions. The family of minichromosome maintenance (MCM) proteins plays an important role not only in DNA replication but also in DDR. Here, we will review the current strides of MCM proteins in these integrated processes as well as the acetylation/deacetylation of MCM proteins and the value of MCMs as biomarkers in cancer.https://www.mdpi.com/2073-4409/14/1/12minichromosome maintenance (MCM)DNA replicationorigin recognition complex (ORC)pre-replication complex (pre-RC)cell cycle checkpointreplication stress |
| spellingShingle | Agnes Malysa Xiaohong Mary Zhang Gerold Bepler Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response Cells minichromosome maintenance (MCM) DNA replication origin recognition complex (ORC) pre-replication complex (pre-RC) cell cycle checkpoint replication stress |
| title | Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response |
| title_full | Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response |
| title_fullStr | Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response |
| title_full_unstemmed | Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response |
| title_short | Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response |
| title_sort | minichromosome maintenance proteins from dna replication to the dna damage response |
| topic | minichromosome maintenance (MCM) DNA replication origin recognition complex (ORC) pre-replication complex (pre-RC) cell cycle checkpoint replication stress |
| url | https://www.mdpi.com/2073-4409/14/1/12 |
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