Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.

Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.

Complex diseases result from molecular changes induced by multiple genetic factors and the environment. To derive a systems view of how genetic loci interact in the context of tissue-specific molecular networks, we constructed an F2 intercross comprised of >500 mice from diabetes-resistant (B6) a...

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Main Authors: Zhidong Tu, Mark P Keller, Chunsheng Zhang, Mary E Rabaglia, Danielle M Greenawalt, Xia Yang, I-Ming Wang, Hongyue Dai, Matthew D Bruss, Pek Y Lum, Yun-Ping Zhou, Daniel M Kemp, Christina Kendziorski, Brian S Yandell, Alan D Attie, Eric E Schadt, Jun Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003107&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003107&type=printable

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