Impact of celastrol on mitochondrial dynamics and proliferation in glioblastoma

Impact of celastrol on mitochondrial dynamics and proliferation in glioblastoma

Abstract Background Targeting mitochondrial dynamics offers promising strategies for treating glioblastoma multiforme. Celastrol has demonstrated therapeutic effects on various cancers, but its impact on mitochondrial dynamics in glioblastoma multiforme remains largely unknown. We studied the effect...

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Main Authors: Lei Liang, Wenying Lv, Gang Cheng, Mou Gao, Junzhao Sun, Ning Liu, Hanbo Zhang, Baorui Guo, Jiayu Liu, Yanteng Li, Shengqiang Xie, Jiangting Wang, Junru Hei, Jianning Zhang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Celastrol
Mitochondrial dynamics
Glioblastoma
Oxidative stress
CDK1 protein
Drug repurposing
Online Access:https://doi.org/10.1186/s12885-025-13733-9
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https://doi.org/10.1186/s12885-025-13733-9

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