The phosphatase PPM1F, a negative regulator of integrin activity, is essential for embryonic development and controls tumor cell invasion

The phosphatase PPM1F, a negative regulator of integrin activity, is essential for embryonic development and controls tumor cell invasion

Abstract Background The Mn2+/Mg2+-dependent Ser/Thr phosphatase PPM1F was identified to control integrin activity. Furthermore, PPM1F regulates several protein kinases known to be involved in organizing the cytoskeleton and other cellular functions. Therefore, PPM1F appears critical for a multitude...

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Bibliographic Details
Main Authors: Tanja M. Grimm, Nina I. Dierdorf, Marleen Herbinger, Sarah Baumgärtner, Erik Sontowski, Christoph Paone, Timo Baade, Christof R. Hauck
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Biology
Subjects:
Cell adhesion
FilaminA
Integrin activity
Protein phosphatase
PPM1F
Talin
Online Access:https://doi.org/10.1186/s12915-025-02254-3
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https://doi.org/10.1186/s12915-025-02254-3

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