USP14 inhibition enhances Parkin-independent mitophagy in iNeurons

USP14 inhibition enhances Parkin-independent mitophagy in iNeurons

Loss of proteostasis is well documented during physiological aging and depends on the progressive decline in the activity of two major degradative mechanisms: the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway. This decline in proteostasis is exacerbated in age-associated neur...

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Bibliographic Details
Main Authors: Greta Bernardo, Miguel A. Prado, Anna Roshani Dashtmian, Mariavittoria Favaro, Sofia Mauri, Alice Borsetto, Elena Marchesan, Joao A. Paulo, Steve P. Gygi, Daniel J. Finley, Elena Ziviani
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
USP14
UPS
Autophagy
Mitophagy
PINK1
Parkin
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004298
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http://www.sciencedirect.com/science/article/pii/S1043661824004298

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