Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models

Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models

ObjectivesThe disruption of blood-brain barrier (BBB) is associated with poor outcomes of TBI patients. Sphingosine-1-phosphate receptor 2 (S1pr2), a member of the G protein-coupled receptor family, is involved in endothelial activation and the regulation of vascular integrity. We hypothesized that...

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Bibliographic Details
Main Authors: Hongbo Cheng, Yijiao Men, Yaqing An, Jiegang Yu, Gengshen Zhang, Jiaming Li, Xiaoliang Wang, Guozhu Sun, Yang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
traumatic brain injury
S1pr2
blood-brain barrier
endothelial cells
MMP-9
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1448570/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1448570/full

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