Modular Combinatorial DNA Assembly of Group B Streptococcus Capsular Polysaccharide Biosynthesis Pathways to Expediate the Production of Novel Glycoconjugate Vaccines

Modular Combinatorial DNA Assembly of Group B Streptococcus Capsular Polysaccharide Biosynthesis Pathways to Expediate the Production of Novel Glycoconjugate Vaccines

Background/objectives: <i>Streptococcus agalactiae</i> (or Group B Streptococcus, GBS) is a major cause of neonatal meningitis globally. There are 10 serotypes of GBS, which are distinguished by their capsular polysaccharide (CPS) structure, with serotypes Ia, Ib, II, III, IV and V respo...

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Bibliographic Details
Main Authors: Mark A. Harrison, Elizabeth Atkins, Alexandra Faulds-Pain, John T. Heap, Brendan W. Wren, Ian J. Passmore
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Vaccines
Subjects:
glycobiology
glycoconjugates
vaccines
DNA assembly
group B Streptococcus
start-stop assembly
Online Access:https://www.mdpi.com/2076-393X/13/3/279
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