Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells

Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells

Abstract Neuroglobin (NGB) is a hexacoordinated hemeprotein mainly expressed in neurons. Following its upregulation and mitochondrial localization, NGB plays a pro-survival role against neuronal stress. Previously, we built a stable NGB-FLAG-overexpressing neuroblastoma cell line and showed that NGB...

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Main Authors: Valeria Manganelli, Michele Costanzo, Daniela Caissutti, Illari Salvatori, Niccolò Candelise, Emiliano Montalesi, Giovanna De Simone, Alberto Ferri, Tina Garofalo, Maurizio Sorice, Margherita Ruoppolo, Agostina Longo, Roberta Misasi
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Neuroglobin
Raptor
Autophagy
Neuroblastoma cells
Online Access:https://doi.org/10.1038/s41598-025-91701-w
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https://doi.org/10.1038/s41598-025-91701-w

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