Signal transduction pathways controlling Ins2 gene activity and beta cell state transitions

Signal transduction pathways controlling Ins2 gene activity and beta cell state transitions

Summary: Pancreatic β cells exist in low and high insulin gene activity states that are dynamic on a scale of hours to days. Here, we used live 3D imaging, mass spectrometry proteomics, and targeted perturbations of β cell signaling to comprehensively investigate Ins2(GFP)HIGH and Ins2(GFP)LOW β cel...

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Bibliographic Details
Main Authors: Chieh Min Chu, Bhavya Sabbineni, Haoning Howard Cen, Xiaoke Hu, WenQing Grace Sun, George P. Brownrigg, Yi Han Xia, Jason Rogalski, James D. Johnson
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Biological sciences
Cell biology
Specialized functions of cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225002755
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http://www.sciencedirect.com/science/article/pii/S2589004225002755

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