SMAD3 and HIF-1α orchestrate metabolic transition to aerobic glycolysis as a critical prerequisite for spontaneous reprogramming of spermatogonial stem cells

SMAD3 and HIF-1α orchestrate metabolic transition to aerobic glycolysis as a critical prerequisite for spontaneous reprogramming of spermatogonial stem cells

Abstract Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why the addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transitio...

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Bibliographic Details
Main Authors: Yihui Cai, Jian Wen, Hongyang Liu, Rui Wei, Xiaoxiao Li, Yao Dong, Keren Cheng, Kang Zou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Aerobic glycolysis
Cell fate
Cellular plasticity
Germline-to-pluripotent transition
HIF-1A activation
Metabolic reprogramming
Online Access:https://doi.org/10.1186/s13287-025-04541-w
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https://doi.org/10.1186/s13287-025-04541-w

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