A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate

A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate

Abstract d-2-Hydroxyglutarate (d-2-HG) is a functional endogenous metabolite in various domains of life. Its abnormal accumulation promotes human tumorigenesis. Convenient d-2-HG testing for diagnosis and prognosis of d-2-HG-related diseases remains technically challenging, and there is no analytica...

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Main Authors: Yidong Liu, Zhaoqi Kang, Rong Xu, Shuang Hou, Lingru Gong, Leilei Guo, Kaiyu Gao, Xianzhi Xu, Xiaoxu Tan, Dan Xiao, Wen Zhang, Gang Wang, Shaowu Ou, Jinqu Hu, Jiyuan Liu, Chuanjuan Lü, Cuiqing Ma, Ping Xu, Chao Gao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62225-8
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https://doi.org/10.1038/s41467-025-62225-8

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